2025 10th International Conference on Health, Medicine and Life Sciences

Dr. Haiyun Xu, Professor

School of Mental Health, Wenzhou Medical University, Wenzhou, China

Biography:  Dr. Haiyun Xu graduated from Peking Union Medical College in July 1996 with a doctorate in Medicine. In September of this year, he started his work at Medical College of Wisconsin (USA), as a postdoctoral fellow (PDF) in Neuroscience. Since then, he had worked in a few academic institutes of USA and Canada as a PDF and a principal investigator (PI) for 15 years. From 2011 to 2019, he was engaged as a Distinguished Professor by Shantou University Medical College (SUMC), functioning as the executive director of the Joint Laboratory of Biological Psychiatry by SUMC and University of Manitoba (Canada). Since October 2019, he has served as a professor and department chair, Wenzhou Medical University, as well as the Chief Clinical Researcher of Wenzhou Kangning Hospital. His research interests cover wide subfields of Biological Psychiatry and Psychopharmacology. He has participated in and presided over a couple of scientific projects funded by the NIH (USA), MRC and CIHR (Canada), as well as the National Natural Science Foundation of China. He has published >120 papers in academic journals and been serving on editorial boards of 16 international academic journals. In 2023 and 2024, he was ranked one of the world's top scientists in neuroscience.

Topic: Demonstration of the Pathway from DA Elevation Through Mitochondrial Dysfunction to Hypomyelination in the Pathogenesis of Schizophrenia: in Vivo and in Vitro Studies

Abstract: The data from the in vivo experiments demonstrate a pathway from dopamine (DA) elevation through mitochondrial dysfunction to hypomyelination in the mouse brain, which provides a novel insight into the negative symptoms and cognitive impairment seen in schizophrenia patients. The amelioration of DA-induced mitochondrial dysfunction and hypomyelination by N-acetylcysteine in cultured oligodendrocytes offers a theoretical basis for targeting mitochondria and oligodendrocytes in treating the patients.

Dr. Jun Ren, Professor

Department of Cardiology, Zhongshan Hospital Fudan University, Shanghai, China

Biography:  Dr. Jun Ren is a professor in Department of Cardiology at Zhongshan Hospital Fudan University. He held full professorship in University of Wyoming and University of Washington between 2002 and 2023. His major area of research is cardiac pathophysiology in alcoholism, diabetes, obesity and aging. His research was funded by the National Science Foundation of China, American Diabetes Association and NIH (33+ million). He is a first or corresponding author of more than 700 peer-reviewed papers (H index=120). Ranks among the top 400 in the cardiovascular field globally. He has served as an editor or on editorial board for a number of journals including Science Bulletin, Hypertension, Diabetes, BBA Molecular Basis of Disease.

Topic: Dynamic Regulation and Intervention of Aberrant Mitochondria-Endoplasmic Reticulum Interaction and Metabolic Reprogramming in Heart Failure

Abstract: Heart failure (HF) becomes one of the leading causes of death, with rising incidence and mortality rates. Increasing evidence suggests that changes in myocardial cell metabolism play a central role in the pathogenesis of HF. Under normal conditions, the heart efficiently generates energy through fatty acid oxidation to maintain stable and continuous pumping function. However, in HF, this balance is disrupted, and the heart shifts from fatty acid oxidation to glycolysis for energy production. Although glycolysis rapidly produces ATP in the short term, its efficiency is much lower than that of fatty acid oxidation, leading to a loss of metabolic flexibility. This metabolic disturbance worsens cardiac function, creating a vicious cycle. Despite advancements in HF research, little is known about the deeper molecular mechanisms underlying metabolic reprogramming, particularly the synergistic effects of mitochondrial-endoplasmic reticulum (MAM) interaction abnormalities and glucose-lipid metabolic reprogramming. Both mitochondria and the endoplasmic reticulum are essential for cellular energy production and lipid/protein synthesis, and their interaction plays a key role in HF-associated metabolic alterations. Investigating this complex regulatory network is crucial for understanding HF pathogenesis and developing effective therapeutic strategies.